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However, a post hoc analysis demonstrated that the intervention was effective among the subgroup of 158 women with BMI 25 kg/m 2 (-0.86 kg/m 2

NICE approved semaglutide (Wegovy) for weight management in specialist NHS weight management services in 2023 (TA875), but availability is limited to patients with: BMI 35 kg/m with at least one weight-related comorbidity, or BMI 30 kg/m with exceptional circumstances Lower BMI thresholds apply for people from some minority ethnic groups (typically 27.5 kg/m) Participation in a specialist weight management programme Treatment limited to a maximum of 2 years Access varies by region due to local integrated care board (ICB) implementation decisions and limited NHS specialist service capacity

Rather than restoring blood flow, it activates melanocortin receptors in the hypothalamus the same central arousal centers responsible for sexual anticipation and erotic motivation

As treated patient volumes continue to expand, innovators must also manage rebates and patient assistance very carefully to protect brand net margins

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